الفرق بين المراجعتين لصفحة: «سبيرونولاكتون»
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كنان الطرح (نقاش | مساهمات) لا ملخص تعديل |
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{{Drugbox | |||
| English = Spironolactone | |||
| Watchedfields = changed | |||
| verifiedrevid = 470470172 | |||
| IUPAC_name = 7α-acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone<br />or<br />17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid, γ-lactone acetate | |||
| image = Spironolactone_structure.svg | |||
== | <!--Clinical data--> | ||
| tradename = Aldactone | |||
| Drugs.com = {{drugs.com|monograph|spironolactone}} | |||
| MedlinePlus = a682627 | |||
| pregnancy_AU = B3 | |||
| pregnancy_US = C | |||
| legal_UK = POM | |||
| legal_US = Rx-only | |||
| routes_of_administration = [[Mouth|Oral]] | |||
<!--Pharmacokinetic data--> | |||
| bioavailability = | |||
| protein_bound = 90%+<ref name="Brittain2002">{{cite book | author = Harry G. Brittain | title = Analytical Profiles of Drug Substances and Excipients | url = http://books.google.com/books?id=RMN5zMW64ZEC&pg=PA309 | accessdate = 27 May 2012 | date = 26 November 2002 | publisher = Academic Press | isbn = 978-0-12-260829-2 | page = 309}}</ref> | |||
| metabolism = [[Liver|Hepatic]] | |||
| elimination_half-life = 1.3-2 hours | |||
| excretion = [[Urine]], [[bile]] | |||
== | <!--Identifiers--> | ||
| CASNo_Ref = {{cascite|correct|CAS}} | |||
| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 52-01-7 | |||
| ATC_prefix = C03 | |||
| ATC_suffix = DA01 | |||
| ATC_supplemental = | |||
| PubChem = 5833 | |||
| IUPHAR_ligand = 2875 | |||
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | |||
| DrugBank = DB00421 | |||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 5628 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = 27O7W4T232 | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D00443 | |||
| ChEBI_Ref = {{ebicite|correct|EBI}} | |||
| ChEBI = 9241 | |||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | |||
| ChEMBL = 1393 | |||
== | <!--Chemical data--> | ||
416.574 g/mol | | C = 24 | H = 32 | O = 4 | S = 1 | ||
| molecular_weight = 416.574 g/mol | |||
| smiles = O=C5O[C@@]4([C@@]3([C@H]([C@@H]2[C@H](SC(=O)C)C/C1=C/C(=O)CC[C@]1(C)[C@H]2CC3)CC4)C)CC5 | |||
| InChI = 1/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1 | |||
| InChIKey = LXMSZDCAJNLERA-ZHYRCANABW | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChI = 1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1 | |||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChIKey = LXMSZDCAJNLERA-ZHYRCANASA-N | |||
}} | |||
'''سبيرونولاكتون (Spironolactone)''' | |||
مدر للبول حافظ للبوتاسيوم وخافض للتوتر الشرياني، يستخدم لعلاج الذومة المترافقة مع فرط في إفراز الألدوستيرون وفي حالات نقص البوتاسيوم ولعلاج الشعرانية عند النساء | |||
{{بذرة}} | {{بذرة}} | ||
مراجعة 21:07، 1 مايو 2013
| |
|---|---|
| Systematic (IUPAC) name | |
| 7α-acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone or 17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid, γ-lactone acetate | |
| Clinical data | |
| Trade names | Aldactone |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682627 |
| Pregnancy cat. | B3 (AU) C (US) |
| Legal status | POM (UK) ℞-only (US) |
| Routes | Oral |
| Pharmacokinetic data | |
| Protein binding | 90%+[1] |
| Metabolism | Hepatic |
| Half-life | 1.3-2 hours |
| Excretion | Urine, bile |
| Identifiers | |
| CAS number | 52-01-7 
|
| ATC code | C03DA01 |
| PubChem | CID 5833 |
| IUPHAR ligand | 2875 |
| DrugBank | DB00421 |
| ChemSpider | 5628
|
| UNII | 27O7W4T232
|
| KEGG | D00443
|
| ChEBI | CHEBI:9241
|
| ChEMBL | CHEMBL1393
|
| Chemical data | |
| Formula | C24H32O4S |
| Mol. mass | 416.574 g/mol |
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 (what is this?) (verify) | |
سبيرونولاكتون (Spironolactone) مدر للبول حافظ للبوتاسيوم وخافض للتوتر الشرياني، يستخدم لعلاج الذومة المترافقة مع فرط في إفراز الألدوستيرون وفي حالات نقص البوتاسيوم ولعلاج الشعرانية عند النساء
- ↑ Harry G. Brittain (26 November 2002). Analytical Profiles of Drug Substances and Excipients. Academic Press. p. 309. ISBN 978-0-12-260829-2. Retrieved 27 May 2012.