الفرق بين المراجعتين لصفحة: «اسلابريم»
كنان الطرح (نقاش | مساهمات) لا ملخص تعديل |
كنان الطرح (نقاش | مساهمات) لا ملخص تعديل |
||
| سطر 1: | سطر 1: | ||
{{Drugbox | |||
| English = Iclaprim | |||
| Verifiedfields = changed | |||
| Watchedfields = changed | |||
| verifiedrevid = 416967709 | |||
| IUPAC_name = (''RS'')-5-[(2- cyclopropyl-7,8-dimethoxy-2''H''-chromen-5-yl)methyl]pyrimidine-2,4-diamine | |||
| image = Iclaprim.svg | |||
| width = 200px | |||
| imagename = 1 : 1 mixture (racemate) | |||
| drug_name = Iclaprim | |||
<!--Clinical data--> | |||
| tradename = | |||
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | |||
| pregnancy_US = <!-- A / B / C / D / X --> | |||
| pregnancy_category = | |||
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | |||
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | |||
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | |||
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | |||
| legal_status = Investigational | |||
| routes_of_administration = [[Intravenous therapy|Intravenous]] (oral under investigation) | |||
<!--Pharmacokinetic data--> | |||
| bioavailability = Good (oral)<ref name=Kohlhoff/> | |||
| protein_bound = | |||
| metabolism = | |||
| elimination_half-life = | |||
| excretion = | |||
<!--Identifiers--> | |||
| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 192314-93-5 | |||
| ATC_prefix = J01 | |||
| ATC_suffix = EA03 | |||
| PubChem = 213043 | |||
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | |||
| DrugBank = | |||
| UNII_Ref = {{fdacite|changed|FDA}} | |||
| UNII = 42445HUU0O | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D08337 | |||
| ChEMBL_Ref = {{ebicite|changed|EBI}} | |||
| ChEMBL = 134561 | |||
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | |||
| ChemSpiderID = 184736 | |||
| InChI = 1/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23) | |||
| InChIKey = HWJPWWYTGBZDEG-UHFFFAOYAK | |||
| StdInChI_Ref = {{stdinchicite|changed|chemspider}} | |||
| StdInChI = 1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23) | |||
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | |||
| StdInChIKey = HWJPWWYTGBZDEG-UHFFFAOYSA-N | |||
<!--Chemical data--> | |||
| C=19 | H=22 | N=4 | O=3 | |||
| molecular_weight = 354.403 g/mol | |||
| smiles = COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC | |||
'''اسلابريم (Iclaprim)''' | '''اسلابريم (Iclaprim)''' | ||
==الزمرة== | ==الزمرة== | ||
مراجعة 01:40، 2 أغسطس 2013
{{Drugbox | English = Iclaprim | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 416967709 | IUPAC_name = (RS)-5-[(2- cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine | image = Iclaprim.svg | width = 200px | imagename = 1 : 1 mixture (racemate) | drug_name = Iclaprim
| tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Investigational | routes_of_administration = Intravenous (oral under investigation)
| bioavailability = Good (oral)[1] | protein_bound = | metabolism = | elimination_half-life = | excretion =
| CAS_number_Ref = 
| CAS_number = 192314-93-5
| ATC_prefix = J01
| ATC_suffix = EA03
| PubChem = 213043
| DrugBank_Ref = قالب:علامة اختيار
| DrugBank =
| UNII_Ref = 
| UNII = 42445HUU0O
| KEGG_Ref =
| KEGG = D08337
| ChEMBL_Ref =
| ChEMBL = 134561
| ChemSpiderID_Ref =
| ChemSpiderID = 184736
| InChI = 1/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)
| InChIKey = HWJPWWYTGBZDEG-UHFFFAOYAK
| StdInChI_Ref =
| StdInChI = 1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)
| StdInChIKey_Ref =
| StdInChIKey = HWJPWWYTGBZDEG-UHFFFAOYSA-N
| C=19 | H=22 | N=4 | O=3 | molecular_weight = 354.403 g/mol | smiles = COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC اسلابريم (Iclaprim)
الزمرة
الاستطباب
- التهابات الجلد المعقدة والتهابات الأنسجة الرخوة التي تسببها البكتيريا المقاومة للمضادات الحيوية.
- التهاب أنسجة الجلد الناجمة عن المكورات العنقودية الذهبية المقاومة للميتيسيلين.
الأشكال الصيدلانية
- حقن وريدي
- يمكن أن تُؤخذ فموياً.
- ↑ خطأ استشهاد: وسم
<ref>غير صحيح؛ لا نص تم توفيره للمراجع المسماةKohlhoff