فوستيديل
(بالتحويل من Fostedil)
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| |
|---|---|
| Systematic (IUPAC) name | |
| diethyl [4-(1,3-benzothiazol-2-yl)benzyl]phosphonate | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 75889-62-2 |
| ATC code | None |
| PubChem | CID 53421 |
| ChemSpider | 48253 |
| UNII | D41WS786UL 
|
| KEGG | D04260 |
| ChEMBL | CHEMBL39516 |
| Chemical data | |
| Formula | C18NO3PS |
| Mol. mass | 361.40 g/mol |
| |
فوستيديل Fostedil هو موسع وعائي يعمل كحاصر لقنوات الكالسيوم، وكان في طور التطوير لعلاج حالات القلب (كالذبحة الصدرية) ولكنه لم يسوق.[1][2][3][4]
له تأثير خافض للضغط ومضاد للروماتيزم.[5][6][7]
الاسماء التجارية
- 986,A-53
- KB-944
الاصطناع
مصادر
- ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ↑ Khurmi NS, Bowles MJ, O'Hara MJ, Lahiri A, Raftery EB (1985). "Ambulatory monitoring and exercise testing in the evaluation of a new long-acting calcium ion antagonist KB-944 (Fostedil) for the treatment of exertional angina pectoris". International Journal of Cardiology. 9 (3): 289–302. PMID 3902675. doi:10.1016/0167-5273(85)90027-0. Unknown parameter
|month=ignored (|date=suggested) (help) - ↑ Morita T, Yoshino K, Kanazawa T, Ito K, Nose T (1982). "Vasodilator action of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1037–42. PMID 6890822.
- ↑ Morita T, Kanazawa T, Ito K, Nose T (1982). "Vasodilator mechanism of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1043–6. PMID 6890823.
- ↑ Morita T, Kanazawa T, Ito K, Nose T (1982). "Antihypertensive effect of KB-944, a new calcium antagonist, in conscious normotensive and hypertensive rats". Arzneimittel-Forschung. 32 (9): 1047–52. PMID 6890824.
- ↑ Morita T, Ito K, Nose T (1982). "Cardiac action of KB-944, a new calcium antagonist". Arzneimittel-Forschung. 32 (9): 1053–5. PMID 6890825.
- ↑ Yoshidomi M, Sukamoto T, Morita T, Ito K, Nose T (1982). "Antiarrhythmic effect of KB-944, a new calcium antagonist. A comparison with verapamil and diltiazem". Arzneimittel-Forschung. 32 (9): 1056–9. PMID 6890826.
- ↑ Yoshino K, Kohno T, Uno T, Morita T, Tsukamoto G (1986). "Organic phosphorus compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as potent calcium antagonistic vasodilator". Journal of Medicinal Chemistry. 29 (5): 820–5. PMID 3701791. doi:10.1021/jm00155a037. Unknown parameter
|month=ignored (|date=suggested) (help)
