الفرق بين المراجعتين لصفحة: «كيتوكونازول»
(أنشأ الصفحة ب'==المرة الدوائية== مضاد فطري يستخدم جهازياً وموضعياً == الاستطبابات == *علاج الانتانات الفطرية م...') |
كنان الطرح (نقاش | مساهمات) لا ملخص تعديل |
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| سطر 1: | سطر 1: | ||
== | {{Drugbox | ||
| English = Ketoconazole | |||
| verifiedrevid = 457114462 | |||
| IUPAC_name = 1-[4-(4-{[(2''R'',4''S'')-2-(2,4-Dichlorophenyl)-2-(1''H''-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | |||
| image = Ketoconazole2.png | |||
| width = 300 | |||
| image2 = Ketoconazole 3D balls 1jin.png | |||
| width2 = 200 | |||
<!-- Clinical data --> | |||
| tradename = Nizoral | |||
| Drugs.com = {{drugs.com|monograph|ketoconazole}} | |||
| MedlinePlus = a682816 | |||
| pregnancy_AU = B3 | |||
| pregnancy_US = C | |||
| legal_UK = POM | |||
| legal_US = OTC | |||
| routes_of_administration = [[Oral administration|Oral]], [[topical]] | |||
| licence_US = Ketoconazole | |||
<!-- Pharmacokinetic data --> | |||
| bioavailability = Variable | |||
| protein_bound = 84 to 99% | |||
| metabolism = [[Liver|Hepatic]] | |||
| elimination_half-life = Biphasic: | |||
| excretion = Biliary and [[Kidney|renal]] | |||
<!-- Identifiers --> | |||
| CASNo_Ref = {{cascite|correct|CAS}} | |||
| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 65277-42-1 | |||
| ATC_prefix = J02 | |||
| ATC_suffix = AB02 | |||
| ATC_supplemental = {{ATC|D01|AC08}} {{ATC|G01|AF11}} | |||
| PubChem = 456201 | |||
| IUPHAR_ligand = 2568 | |||
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | |||
| DrugBank = DB01026 | |||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 401695 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = R9400W927I | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D00351 | |||
| ChEBI_Ref = {{ebicite|correct|EBI}} | |||
| ChEBI = 48336 | |||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | |||
| ChEMBL = 75 | |||
<!-- Chemical data --> | |||
| C=26 | H=28 | Cl=2 | N=4 | O=4 | |||
| molecular_weight = 531.431 [[Gram|g]]/[[Mole (unit)|mol]] | |||
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C | |||
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | |||
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | |||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N | |||
}} | |||
{{Drugbox | |||
| English = Ketoconazole | |||
| verifiedrevid = 457114462 | |||
| IUPAC_name = 1-[4-(4-{[(2''R'',4''S'')-2-(2,4-Dichlorophenyl)-2-(1''H''-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | |||
| image = Ketoconazole2.png | |||
| width = 300 | |||
| image2 = Ketoconazole 3D balls 1jin.png | |||
| width2 = 200 | |||
<!-- Clinical data --> | |||
| tradename = Nizoral | |||
| Drugs.com = {{drugs.com|monograph|ketoconazole}} | |||
| MedlinePlus = a682816 | |||
| pregnancy_AU = B3 | |||
| pregnancy_US = C | |||
| legal_UK = POM | |||
| legal_US = OTC | |||
| routes_of_administration = [[Oral administration|Oral]], [[topical]] | |||
| licence_US = Ketoconazole | |||
<!-- Pharmacokinetic data --> | |||
| bioavailability = Variable | |||
| protein_bound = 84 to 99% | |||
| metabolism = [[Liver|Hepatic]] | |||
| elimination_half-life = Biphasic: | |||
| excretion = Biliary and [[Kidney|renal]] | |||
<!-- Identifiers --> | |||
| CASNo_Ref = {{cascite|correct|CAS}} | |||
| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 65277-42-1 | |||
| ATC_prefix = J02 | |||
| ATC_suffix = AB02 | |||
| ATC_supplemental = {{ATC|D01|AC08}} {{ATC|G01|AF11}} | |||
| PubChem = 456201 | |||
| IUPHAR_ligand = 2568 | |||
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | |||
| DrugBank = DB01026 | |||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 401695 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = R9400W927I | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D00351 | |||
| ChEBI_Ref = {{ebicite|correct|EBI}} | |||
| ChEBI = 48336 | |||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | |||
| ChEMBL = 75 | |||
<!-- Chemical data --> | |||
| C=26 | H=28 | Cl=2 | N=4 | O=4 | |||
| molecular_weight = 531.431 [[Gram|g]]/[[Mole (unit)|mol]] | |||
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C | |||
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | |||
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | |||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N | |||
}} | |||
'''كيتوكونازول (Ketoconazole)''' | |||
==الزمرة الدوائية== | |||
مضاد فطري يستخدم جهازياً وموضعياً | مضاد فطري يستخدم جهازياً وموضعياً | ||
مراجعة 14:13، 14 أغسطس 2013
{{Drugbox | English = Ketoconazole | verifiedrevid = 457114462 | IUPAC_name = 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | image = Ketoconazole2.png | width = 300 | image2 = Ketoconazole 3D balls 1jin.png | width2 = 200
| tradename = Nizoral | Drugs.com = monograph | MedlinePlus = a682816 | pregnancy_AU = B3 | pregnancy_US = C | legal_UK = POM | legal_US = OTC | routes_of_administration = Oral, topical | licence_US = Ketoconazole
| bioavailability = Variable | protein_bound = 84 to 99% | metabolism = Hepatic | elimination_half-life = Biphasic: | excretion = Biliary and renal
| CASNo_Ref = 
| CAS_number_Ref =
| CAS_number = 65277-42-1
| ATC_prefix = J02
| ATC_suffix = AB02
| ATC_supplemental = D01AC08 G01AF11
| PubChem = 456201
| IUPHAR_ligand = 2568
| DrugBank_Ref = قالب:علامة اختيار
| DrugBank = DB01026
| ChemSpiderID_Ref =
| ChemSpiderID = 401695
| UNII_Ref =
| UNII = R9400W927I
| KEGG_Ref =
| KEGG = D00351
| ChEBI_Ref =
| ChEBI = 48336
| ChEMBL_Ref =
| ChEMBL = 75
| C=26 | H=28 | Cl=2 | N=4 | O=4
| molecular_weight = 531.431 g/mol
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE
| StdInChI_Ref =
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| StdInChIKey_Ref =
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N
}}
{{Drugbox
| English = Ketoconazole
| verifiedrevid = 457114462
| IUPAC_name = 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
| image = Ketoconazole2.png
| width = 300
| image2 = Ketoconazole 3D balls 1jin.png
| width2 = 200
| tradename = Nizoral | Drugs.com = monograph | MedlinePlus = a682816 | pregnancy_AU = B3 | pregnancy_US = C | legal_UK = POM | legal_US = OTC | routes_of_administration = Oral, topical | licence_US = Ketoconazole
| bioavailability = Variable | protein_bound = 84 to 99% | metabolism = Hepatic | elimination_half-life = Biphasic: | excretion = Biliary and renal
| CASNo_Ref =
| CAS_number_Ref =
| CAS_number = 65277-42-1
| ATC_prefix = J02
| ATC_suffix = AB02
| ATC_supplemental = D01AC08 G01AF11
| PubChem = 456201
| IUPHAR_ligand = 2568
| DrugBank_Ref = قالب:علامة اختيار
| DrugBank = DB01026
| ChemSpiderID_Ref =
| ChemSpiderID = 401695
| UNII_Ref =
| UNII = R9400W927I
| KEGG_Ref =
| KEGG = D00351
| ChEBI_Ref =
| ChEBI = 48336
| ChEMBL_Ref =
| ChEMBL = 75
| C=26 | H=28 | Cl=2 | N=4 | O=4
| molecular_weight = 531.431 g/mol
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE
| StdInChI_Ref =
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| StdInChIKey_Ref =
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N
}}
كيتوكونازول (Ketoconazole)
الزمرة الدوائية
مضاد فطري يستخدم جهازياً وموضعياً
الاستطبابات
- علاج الانتانات الفطرية مثل داء المبيضات والسلاق الفموي والفطار البرعمي وداء النوسجات ونظيره الشعيه الكروانيةوداء المبيضات الجلدي المخاطي المزمن وبعض الفطور الجلدية الأخرى
- يطبق موضعياً لعلاج السعفة الجسد وسعفة الأرفاغ والسعفة المبرقشة وداء المبيضات الجلدي والتهاب الجلد المثي
الاستخدام أثناء الحمل
من المجموعة C
مضادات الاستطباب
- فرط الحساسية لهذا المستحضر
- لا يصلح لعلاج الانتان الفطري للجملة العصبية المركزية بسبب ضعف انتشاره فيها
- لا يجوز إعطاءه مع تيرفينادين أو سيزابريد لأنه قد يسبب لانظميات قلبية مميتة
تحذيرات
يستخدم بحذر عند مرضى الوظيفة الكبدية، وقد ترافق استخدامه أحياناً مع سمية كبدية مميتة
