عرض مصدر Tuftelin

{{Infobox_gene}}
'''Tuftelin''' is an acidic [[Phosphorylation|phosphorylated]] [[glycoprotein]] found in [[tooth]] [[tooth enamel|enamel]].  In humans, the Tuftelin protein is encoded by the ''TUFT1'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: TUFT1 tuftelin 1| url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7286| accessdate = }}</ref><ref name="pmid7919663">{{cite journal |vauthors=Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW | title = Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization | journal = Mamm. Genome | volume = 5 | issue = 7 | pages = 461–2 |date=July 1994 | pmid = 7919663 | doi = 10.1007/BF00357011| url =  }}</ref>

== Function ==

This protein is formed for a short time during [[amelogenesis]].  The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during [[tooth development]].<ref name="pmid2672884">{{cite journal | author = Deutsch D | title = Structure and function of enamel gene products | journal = Anat. Rec. | volume = 224 | issue = 2 | pages = 189–210 |date=June 1989 | pmid = 2672884 | doi = 10.1002/ar.1092240209 | url =  }}</ref><ref name="pmid1874744">{{cite journal |vauthors=Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF | title = Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein | journal = J. Biol. Chem. | volume = 266 | issue = 24 | pages = 16021–8 |date=August 1991 | pmid = 1874744 | doi = | url = http://www.jbc.org/cgi/content/abstract/266/24/16021 }}</ref>

Other significant proteins in enamel are [[amelogenin]]s, [[enamelin]]s, and [[ameloblastin]]s.

== Research ==
The human encoding [[gene]] for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the [[Hebrew University]]-[[Hadassah]] [[List of dental schools in Israel|School of Dental Medicine]] in [[Jerusalem]].<ref name="pmid7919663"/>

==Interactions==
Tuftelin has been shown to [[Protein-protein interaction|interact]] with [[TFIP11]].<ref name=pmid10806191>{{cite journal |last=Paine |first=C T |authorlink= |author2=Paine M L |author3=Luo W |author4=Okamoto C T |author5=Lyngstadaas S P |author6=Snead M L  |date=July 2000  |title=A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts |journal=J. Biol. Chem. |volume=275 |issue=29 |pages=22284–92 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10806191 |doi = 10.1074/jbc.M000118200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

== References ==
{{Reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Deutsch D, Leiser Y, Shay B, etal |title=The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues.|journal=Connect. Tissue Res. |volume=43 |issue= 2–3 |pages= 425–34 |year= 2003 |pmid= 12489194 |doi=  10.1080/03008200290001186}}
*{{cite journal   |vauthors=Deutsch D, Palmon A, Young MF, etal |title=Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization|journal=Mamm. Genome |volume=5 |issue= 7 |pages= 461–2 |year= 1994 |pmid= 7919663 |doi=10.1007/BF00357011  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene|volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal   |vauthors=Paine CT, Paine ML, Luo W, etal |title=A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts|journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22284–92 |year= 2000 |pmid= 10806191 |doi= 10.1074/jbc.M000118200 }}
*{{cite journal   |vauthors=Bashir MM, Abrams WR, Tucker T, etal |title=Molecular cloning and characterization of the bovine and human tuftelin genes |journal=Connect. Tissue Res. |volume=39 |issue= 1–3 |pages= 13–24; discussion 63–7 |year= 2000 |pmid= 11062985 |doi=10.3109/03008209809023908  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
*{{cite journal   |vauthors=Mao Z, Shay B, Hekmati M, etal |title=The human tuftelin gene: cloning and characterization |journal=Gene |volume=279 |issue= 2 |pages= 181–96|year= 2002 |pmid= 11733143 |doi=10.1016/S0378-1119(01)00749-1  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet.|volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B|pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue|pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441|issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}

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[[Category:Teeth]]


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