عرض مصدر قالب:Ion channel modulators

{{Navbox
 | name = Ion channel modulators
 | title = [[Channel modulator|Ion channel modulator]]s
 | state = {{{state<includeonly>|collapsed</includeonly>}}}
 | listclass = hlist
 | groupstyle = text-align:center;

 | group1 = [[Calcium channel|Calcium]]
 | list1 = {{Navbox|child
 | groupstyle = text-align:center;
 | groupwidth = 5em;

   | group1 = {{abbrlink|VDCCs|Voltage-dependent calcium channels}}
   | list1 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Calcium channel blocker|Blocker]]s
     | list1 =
* '''[[L-type calcium channel|L-type-selective]]:''' ''[[Dihydropyridine]]s:'' [[Amlodipine]]
* [[Aranidipine]]
* [[Azelnidipine]]
* [[Barnidipine]]
* [[Clevidipine]]
* [[Cronidipine]]
* [[Darodipine]]
* [[Dexniguldipine]]
* [[Elgodipine]]
* [[Elnadipine]]
* [[Felodipine]]
* [[Flordipine]]
* [[Furnidipine]]
* [[Iganidipine]]
* [[Isradipine]]
* [[Lacidipine]]
* [[Lemildipine]]
* [[Lercanidipine]]
* [[Levamlodipine]]
* [[Levniguldipine]]
* [[Manidipine]]
* [[Barnidipine|Mepirodipine]]
* [[Mesudipine]]
* [[Nicardipine]]
* [[Nifedipine]]
* [[Niguldipine]]
* [[Niludipine]]
* [[Nilvadipine]]
* [[Nimodipine]]
* [[Nisoldipine]]
* [[Nitrendipine]]
* [[Olradipine]]
* [[Oxodipine]]
* [[Palonidipine]]
* [[Pranidipine]]
* [[Riodipine|Ryodipine (riodipine)]]
* [[Sagandipine]]
* [[Sornidipine]]
* [[Teludipine]]
* [[Tiamdipine]]
* [[Trombodipine]]
* [[Vatanidipine]]; ''[[Diltiazem]] derivatives:'' [[Clentiazem]]
* [[Diltiazem]]
* [[Iprotiazem]]
* [[Nictiazem]]
* [[Siratiazem]]; ''[[Arylalkylamine|Phenylalkylamine]]s:'' [[Anipamil]]
* [[Dagapamil]]
* [[Devapamil]]
* [[Dexverapamil]]
* [[Emopamil]]
* [[Etripamil]]
* [[Falipamil]]
* [[Gallopamil]]
* [[Levemopamil]]
* [[Nexopamil]]
* [[Norverapamil]]
* [[Ronipamil]]
* [[Tiapamil]]
* [[Verapamil]]; ''Others:'' [[AH-1058]]
* [[Brinazarone]]
* [[Budiodarone]]
* [[Celivarone]]
* [[Cyproheptadine]]
* [[Dronedarone]]
* [[Fantofarone]]
* [[SR-33805]]<!--allosteric blocker-->
* [[Tetrahydropalmatine]]

* '''[[N-type calcium channel|N-type-selective]]:''' [[ω-Conotoxin]]s
* [[ω-Conotoxin GVIA]]
* [[Caroverine]]
* [[Huwentoxin XVI]]
* [[Leconotide|Leconotide (ω-conotoxin CVID)]]
* [[PD-173212]]
* [[Ralfinamide]]
* [[Safinamide]]
* [[Z160]]
* [[Ziconotide|Ziconotide (ω-conotoxin MVIIA)]]

* '''[[P-type calcium channel|P-type-selective]]:''' [[ω-Agatoxin IVA]]
* [[ω-Agatoxin IVB]]

* '''[[R-type calcium channel|R-type-selective]]:''' [[SNX-482]]

* '''[[T-type calcium channel|T-type-selective]]:''' [[ABT-639]]<!--Cav3.2-selective-->
* [[ML-218]]
* [[Niflumic acid]]
* [[NNC 55-0396]]
* [[ProTx I]]<!--Cav3.1-selective-->
* [[Z944]]
* [[Zonisamide]]

* '''Non-selective:''' [[ω-Agatoxin TK]]<!--dual P/Q-type blocker-->
* [[ω-Conotoxin MVIIC]]<!--triple N/P/Q-type blocker-->
* [[Benidipine]]<!--triple L/N/T-type blocker-->
* [[Bepridil]]<!--dual L/T-type blocker-->
* [[Cilnidipine]]<!--dual L/N-type blocker-->
* [[Cinnarizine]]
* [[Dotarizine]]
* [[Efonidipine]]<!--dual L/T-type blocker-->
* [[Flunarizine]]
* [[Lamotrigine]]<!--triple L/N/P-type blocker-->
* [[Levetiracetam]]<!--triple N/P/Q-type blocker-->
* [[Lomerizine]]<!--dual L/T-type blocker-->
* [[Loperamide]]<!--dual L/N-type blocker-->
* [[Mibefradil]]<!--dual L/T-type blocker-->
* [[NP078585]]<!--dual N/T-type blocker-->
* [[Ruthenium red]]<!--dual N/P-type blocker-->
* [[TROX-1]]<!--quadruple N/P/Q/R-type blocker-->

* '''[[Voltage-dependent calcium channel#α2δ Subunit|α<sub>2</sub>δ subunit]]-selective ([[gabapentinoid]]s):''' [[4-Methylpregabalin]]
* [[Arbaclofen]]<!--Weakly-->
* [[Arbaclofen placarbil]]<!--Weakly-->
* [[Atagabalin]]
* [[Baclofen]]<!--Weakly-->
* [[Gabapentin]]
* [[Gabapentin enacarbil]]
* [[Imagabalin]]
* [[Mirogabalin]]
* [[PD-200,347]]
* [[PD-217,014]]
* [[PD-299,685]]
* [[Phenibut]]
* [[Pregabalin]]

* '''Others/unsorted:''' [[Bencyclane]]
* [[Berbamine]]
* [[Bevantolol]]
* [[Canadine]]
* [[Carboxyamidotriazole]]
* [[Cycleanine]]
* [[Dauricine]]
* [[Dimeditiapramine]]
* [[Diproteverine]]
* [[Enpiperate]]
* [[Eperisone]]
* [[Elpetrigine]]
* [[Ethadione]]
* [[Alcohol (drug)|Ethanol (alcohol)]]
* [[Ethosuximide]]
* [[Fasudil]]
* [[Fendiline]]
* [[Fostedil]]
* [[Imepitoin]]
* [[JTV-519]]
* [[Lidoflazine]]
* [[Magnesium]]
* [[Manoalide]]
* [[Mesuximide]]
* [[Monatepil]]
* [[Naftopidil]]
* [[Ochratoxin A]]
* [[Osthol]]
* [[Otilonium bromide]]
* [[Paramethadione]]
* [[Phensuximide]]
* [[Pinaverium]]
* [[Prenylamine]]
* [[Rhynchophylline]]
* [[Sesamodil]]
* [[Silperisone]]
* [[Sipatrigine]]
* [[Terodiline]]
* [[Tetrandrine]]
* [[Tolperisone]]
* [[Trimethadione]]
* [[Valperinol]]

   | group2 = [[Calcium channel opener|Activator]]s
   | list2 =
* '''[[L-type calcium channel|L-type-selective]]:''' [[Bay K8644]]

    }}

}}

 | group2 = [[Potassium channel|Potassium]]
 | list2 = {{Navbox|child
 | groupstyle = text-align:center;
 | groupwidth = 5em;

   | group1 = {{abbrlink|VGKCs|Voltage-gated potassium channels}}
   | list1 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Potassium channel blocker|Blocker]]s
     | list1 =
* [[3,4-Diaminopyridine|3,4-Diaminopyridine (amifampridine)]]
* [[4-Aminopyridine|4-Aminopyridine (fampridine/dalfampridine)]]
* [[Adekalant]]
* [[Almokalant]]
* [[Amiodarone]]
* [[Azimilide]]
* [[Bretylium]]
* [[Bunaftine]]
* [[Charybdotoxin]]
* [[Clamikalant]]
* [[Conotoxin]]s
* [[Dalazatide]]<!--Kv1.3-selective-->
* [[Dendrotoxin]]
* [[Dofetilide]]
* [[Dronedarone]]
* [[E-4031]]
* [[Hanatoxin]]
* [[HgeTx1]]
* [[HsTx1]]
* [[Ibutilide]]
* [[Inakalant]]
* [[Kaliotoxin]]
* [[Linopirdine]]
* [[Lolitrem B]]
* [[Maurotoxin]]
* [[Nifekalant]]
* [[Notoxin]]
* [[Paxilline]]
* [[Pinokalant]]
* [[Quinidine]]
* [[ShK-186]]<!--Kv1.3-selective-->
* [[Sotalol]]
* [[Tedisamil]]
* [[Terikalant]]
* [[Tetraethylammonium]]
* [[Vernakalant]]

* '''[[hERG]] (KCNH2, K<sub>v</sub>11.1)-specific:''' [[Ajmaline]]
* [[Amiodarone]]
* [[AmmTX3]]
* [[Astemizole]]
* [[Azaspiracid]]
* [[AZD1305]]
* [[Azimilide]]
* [[Bedaquiline]]
* [[BeKm-1 toxin|BeKm-1]]
* [[BmTx3]]
* [[BRL-32872]]
* [[Chlorpromazine]]
* [[Cisapride]]
* [[Clarithromycin]]
* [[Darifenacin]]
* [[Dextropropoxyphene]]
* [[Diallyl trisulfide]]
* [[Domperidone]]
* [[E-4031]]
* [[Ergtoxin]]s
* [[Erythromycin]]
* [[Gigactonine]]
* [[Haloperidol]]
* [[Ketoconazole]]
* [[Norpropoxyphene]]
* [[Orphenadrine]]
* [[Pimozide]]
* [[PNU-282,987]]
* [[Promethazine]]
* [[Quinidine]]
* [[Ranolazine]]
* [[Roxithromycin]]
* [[Sertindole]]
* [[Solifenacin]]
* [[Tamulotoxin]]
* [[Terodiline]]
* [[Terfenadine]]
* [[Thioridazine]]
* [[Tolterodine]]
* [[Vanoxerine]]
* [[Vernakalant]]

* '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Linopirdine]]
* [[XE-991]]

     | group2 = [[Potassium channel opener|Activator]]s
     | list2 =
* '''[[KCNQ|KCNQ (K<sub>v</sub>7)]]-specific:''' [[Flupirtine]]
* [[Retigabine]]

    }}

   | group2 = {{abbrlink|IRKs|Inwardly rectifying potassium channel}}
   | list2 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Potassium channel blocker|Blocker]]s
     | list1 =
* '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Acetohexamide]]
* [[Carbutamide]]
* [[Chlorpropamide]]
* [[Glibenclamide|Glibenclamide (glyburide)]]
* [[Glibornuride]]
* [[Glicaramide]]
* [[Gliclazide]]
* [[Glimepiride]]
* [[Glipizide]]
* [[Gliquidone]]
* [[Glisoxepide]]
* [[Glyclopyramide]]
* [[Glycyclamide]]
* [[Metahexamide]]
* [[Mitiglinide]]
* [[Nateglinide]]
* [[Repaglinide]]
* [[Tolazamide]]
* [[Tolbutamide]]

* '''{{abbrlink|GIRK|G protein-coupled inwardly-rectifying potassium channel}}-specific:''' [[Barium]]
* [[Caramiphen]]
* [[Cloperastine]]
* [[Clozapine]]
* [[Dextromethorphan]]
* [[Ethosuximide]]
* [[Ifenprodil]]
* [[Tertiapin]]
* [[Tipepidine]]

     | group2 = [[Potassium channel opener|Activator]]s
     | list2 =
* '''{{abbrlink|K<sub>ATP</sub>|ATP-sensitive potassium channel}}-specific:''' [[Aprikalim]]
* [[Bimakalim]]
* [[Cromakalim]]
* [[Diazoxide]]
* [[Emakalim]]
* [[Levcromakalim]]
* [[Mazokalim]]
* [[Minoxidil]]
* [[Naminidil]]
* [[Nicorandil]]
* [[Pinacidil]]
* [[Rilmakalim]]
* [[Sarakalim]]

* '''{{abbrlink|GIRK|G protein-coupled inwardly-rectifying potassium channel}}-specific:''' [[ML-297|ML-297 (VU0456810)]]

   }}

   | group3 = {{abbrlink|K<sub>Ca</sub>|Calcium-activated potassium channel}}
   | list3 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Potassium channel blocker|Blocker]]s
     | list1 =
* '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Alcohol (drug)|Ethanol (alcohol)]]
* [[GAL-021]]

     | group2 = [[Potassium channel opener|Activator]]s
     | list2 =
* '''[[BK channel|BK<sub>Ca</sub>]]-specific:''' [[Flufenamic acid]]
* [[Meclofenamic acid]]
* [[Niflumic acid]]
* [[Nimesulide]]
* [[Rottlerin|Rottlerin (mallotoxin)]]
* [[Tolfenamic acid]]

   }}

   | group4 = {{abbrlink|K2Ps|Tandem pore domain potassium channel}}
   | list4 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Potassium channel blocker|Blocker]]s
     | list1 =
* [[12-O-Tetradecanoylphorbol-13-acetate]]
* [[Arachidonic acid]]
* [[Fluoxetine]]
* [[Norfluoxetine]]

     | group2 = [[Potassium channel opener|Activator]]s
     | list2 =
* [[Riluzole]]

   }}

}}

 | group3 = [[Sodium channel|Sodium]]
 | list3 = {{Navbox|child
 | groupstyle = text-align:center;
 | groupwidth = 5em;

   | group1 = {{abbrlink|VGSCs|Voltage-gated sodium channels}}
   | list1 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Sodium channel blocker|Blocker]]s
     | list1 =
* ''Antianginals:'' [[Ranolazine]]

* ''Antiarrhythmics (class I):'' [[Ajmaline]]
* [[Aprindine]]
* [[Disopyramide]]
* [[Dronedarone]]
* [[Encainide]]
* [[Flecainide]]
* [[Lidocaine]]
* [[Lorajmine]]
* [[Lorcainide]]
* [[Mexiletine]]
* [[Moracizine|Moricizine]]
* [[Pilsicainide]]
* [[Prajmaline]]
* [[Procainamide]]
* [[Propafenone]]
* [[Quinidine]]
* [[Sparteine]]
* [[Tocainide]]

* ''Anticonvulsants:'' [[Acetylpheneturide]]
* [[Carbamazepine]]
* [[Cenobamate]]
* [[Chlorphenacemide]]
* [[Elpetrigine]]
* [[Eslicarbazepine acetate]]
* [[Ethotoin]]
* [[Fosphenytoin]]
* [[Lacosamide]]
* [[Licarbazepine]]
* [[Mephenytoin]]
* [[Oxcarbazepine]]
* [[Oxitriptyline]]
* [[Phenacemide]]
* [[Pheneturide]]
* [[Phenytoin]]
* [[Rufinamide]]
* [[Sipatrigine]]
* [[Topiramate]]
* [[Sodium valproate]]
* [[Valnoctamide]]
* [[Valproate pivoxil]]
* [[Valproate semisodium]]
* [[Valproic acid]]
* [[Valpromide]]
* [[Zonisamide]]

* ''Local anesthetics:'' [[3-(p-Fluorobenzoyloxy)tropane|''p''FBT]]
* [[Amylocaine]]
* [[Articaine]]
* [[Benzocaine]]
* [[Bupivacaine]] ([[Levobupivacaine]], [[Ropivacaine]])
* [[Butacaine]]
* [[Butamben]]
* [[Chloroprocaine]]
* [[Cinchocaine]]
* [[Cocaine]]
* [[Cyclomethycaine]]
* [[Dimethocaine]]
* [[Diphenhydramine]]
* [[Etidocaine]]
* [[Hexylcaine]]
* [[Iontocaine]]
* [[Lidocaine]]
* [[Mepivacaine]]
* [[Meprylcaine]]
* [[Metabutoxycaine]]
* [[Orthocaine]]
* [[Piperocaine]]
* [[Prilocaine]]
* [[Procaine]]
* [[Propoxycaine]]
* [[Proxymetacaine]]
* [[Risocaine]]
* [[Tetracaine]]
* [[Trimecaine]]

* ''Analgesics:'' [[AZD-3161]]
* [[DSP-2230]]
* [[Funapide]]
* [[GDC-0276]]
* [[NKTR-171]]
* [[PF-04531083]]
* [[PF-05089771]]
* [[Ralfinamide]]
* [[Raxatrigine]]
* [[RG7893|RG7893 (GDC-0287)]]

* ''Toxins:'' [[Conotoxin]]s
* [[Neosaxitoxin]]
* [[Saxitoxin]]
* [[Tetrodotoxin]]

* ''Others:'' [[Buprenorphine]]
* [[Evenamide]]
* [[Menthol]] ([[Mentha|mint]])
* [[Safinamide]]
* [[Tricyclic antidepressant]]s

   | group2 = [[Sodium channel opener|Activator]]s
   | list2 =
* [[Atracotoxin]]s ([[Robustoxin]], [[Versutoxin]])
* [[Ciguatoxin]]s
* [[Poneratoxin]]

   }}

   | group2 = {{abbrlink|ENaC|Epithelial sodium channel}}
   | list2 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Sodium channel blocker|Blocker]]s
     | list1 =
* [[Amiloride]]
* [[Benzamil]]
* [[Triamterene]]

     | group2 = [[Sodium channel opener|Activator]]s
     | list2 =
* [[Solnatide]]

   }}

   | group3 = {{abbrlink|ASICs|Acid-sensing ion channel}}
   | list3 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Sodium channel blocker|Blocker]]s
     | list1 =
* [[A-317567]]
* [[Amiloride]]
* [[Aspirin]]
* [[Ibuprofen]]
* [[PcTX1]]

     | group2 = [[Sodium channel opener|Activator]]s
     | list2 =

  }}

}}

 | group4 = [[Chloride channel|Chloride]]
 | list4 = {{Navbox|child
 | groupstyle = text-align:center;
 | groupwidth = 5em;

   | group1 ={{abbrlink|CaCCs|Calcium-activated chloride channel}}
   | list1 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Chloride channel blocker|Blocker]]s
     | list1 =
* [[Crofelemer]]<!--ANO1-->
* [[DIDS]]<!--ANO1-->
* [[Ethacrynic acid]]
* [[Flufenamic acid]]
* [[Fluoxetine]]
* [[Furosemide]]
* [[Glibenclamide]]
* [[Mefloquine]]
* [[Mibefradil]]
* [[Niflumic acid]]

     | group2 = [[Chloride channel opener|Activator]]s
     | list2 =
* [[Carbachol]]<!--ANO1-->

   }}

   | group2 = {{abbrlink|CFTR|Cystic fibrosis transmembrane conductance regulator}}
   | list2 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Chloride channel blocker|Blocker]]s
     | list1 =
* [[Glibenclamide]]
* [[Lonidamine]]
* [[Piretanide]]

     | group2 = [[Chloride channel opener|Activator]]s
     | list2 =
* [[1,7-Phenanthroline]]
* [[1,10-Phenanthroline]]
* [[4,7-Phenanthroline]]
* [[7,8-Benzoquinoline]]
* [[Ivacaftor]]
* [[Phenanthridine]]

   }}

   | group3 = Unsorted
   | list3 = {{Navbox|child
   | groupstyle = text-align:center;
   | groupwidth = 5em;

     | group1 = [[Chloride channel blocker|Blocker]]s
     | list1 =
* [[Bumetanide]]
* [[Flufenamic acid]]
* [[Meclofenamic acid]]
* [[Mefenamic acid]]
* [[Mepacrine]]
* [[Niflumic acid]]
* [[Talniflumate]]
* [[Tolfenamic acid]]
* [[Trifluoperazine]]

     | group2 = [[Chloride channel opener|Activator]]s
     | list2 =

   }}

 }}

 | group5 = Others
 | list5 = {{Navbox|child
 | groupstyle = text-align:center;
 | groupwidth = 5em;

   | group1 = {{abbrlink|TRPs|Transient receptor potential channels}}
   | list1 = 
* See [[Template:Transient receptor potential channel modulators|here]] instead.

 }}

 | below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]] • [[Template:Transient receptor potential channel modulators|Transient receptor potential channel modulators]]''

}}<noinclude>
{{collapsible option}}
[[Category:Drug templates by receptor, channel, or pump]]
</noinclude>